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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Molecular interaction fields vs. quantum-mechanical-based descriptors in the modelling of lipophilicity of
Giuseppe Ermondi1, Giulia Caron, Mauro Ravera
1CASMedChem Research Group at the Centre for Innovation, Dipartimento di Biotecnologie Molecolari e Scienza della Salute, Università di Torino, Via Quarello 11, 10135 Torino, Italy.
Abstract:
We report QSAR calculations using VolSurf descriptors to model the lipophilicity of 53 Pt(iv) complexes with a diverse range of axial and equatorial ligands. Lipophilicity is measured using an efficient HPLC method. Previous models based on a subset of these data are shown to be inadequate, due to incompatibility of whole molecule descriptors between carboxylato and hydroxido ligands. Instead, the interaction surfaces of complexes with various probes are used as independent descriptors. Partial least squares modelling using three latent variables results in an accurate (R(2) = 0.92) and robust model (Q(2) = 0.87) of lipophilicity, that moreover highlights the importance of size and hydrophobicity terms and the modest relevance of hydrogen bonding.
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