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Multi-centric solid-pseudopapillary neoplasm of the pancreas
Hai-Xia Li1, Ying Zhang, Zun-Guo Du
1Department of Pathology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China.
Medical Oncology (Northwood, London, England)
|December 25, 2012
Summary
Multi-centric solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare condition. This study found multi-centric SPN shares clinical and pathological features with solitary SPN, with excellent prognosis after surgery.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Multi-centric solid-pseudopapillary neoplasm (SPN) of the pancreas is an exceptionally rare tumor with poorly understood clinical and pathological characteristics.
- Only four cases of multi-centric SPN have been previously documented in medical literature.
Observation:
- This study presents three new cases of multi-centric SPN, contributing to a total of seven reported cases.
- The majority of patients (6 out of 7) were female, presenting with non-specific symptoms.
- Observed tumors were typically large, well-demarcated, exhibited cystic degeneration, and had clear margins between lesions.
Findings:
- Histologically, tumors displayed characteristic pseudopapillae formed by uniform cells surrounding delicate blood vessels.
- Immunohistochemical analysis revealed tumor cell positivity for vimentin, synaptophysin, progesterone receptor, and CD10.
- Nuclear localization of β-catenin was a consistent finding in the tumor cells.
Implications:
- Multi-centric SPN exhibits similar clinical and pathological features to solitary SPN.
- Complete surgical resection appears to lead to an excellent prognosis for patients with multi-centric SPN.
- Further research is warranted to fully elucidate the characteristics and optimal management of this rare pancreatic neoplasm.
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