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Updated: May 15, 2026

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
Published on: October 9, 2016
Evidence for broad-spectrum biofilm inhibition by the bacterium Bacillus sp. strain SW9
Zhuoying Wu1, Chengsong Ye, Feng Guo
1Chinese Academy of Sciences, Xiamen, China.
Abstract:
We isolated a Bacillus sp. strain that could display broad-spectrum biofilm inhibition. The broad biofilm prevention could be achieved mainly by direct contact between inhibitor and target cells or was accompanied by an interaction with secreted inhibitory compounds. The repression of cell surface fimbria-like appendages of a biofilm producer was also observed; this was considered to contribute to the reduction in mixed biofilms.
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