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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Published on: December 15, 2023

Hepatitis B and immigrants: a SIMIT multicenter cross-sectional study.

M Fasano1, A Saracino, G Carosi

  • 1Clinic of Infectious Diseases, University of Bari, Bari, Italy.

Infection
|December 25, 2012
PubMed
Summary
This summary is machine-generated.

Immigrants represent 25% of hepatitis B virus (HBV) carriers in Italy, presenting distinct characteristics and lower treatment access compared to native Italians. This highlights disparities in care for HBV-positive migrants.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Increasing migration introduces new chronic hepatitis B virus (HBV) carriers to Italy.
  • The clinical and virological profiles of these HBsAg-positive migrants are not well-defined.

Purpose of the Study:

  • To determine the proportion of HBsAg-positive immigrants in Italy.
  • To compare the characteristics of chronic hepatitis B in migrants versus Italian carriers.

Main Methods:

  • A multicenter, cross-sectional study was conducted across 74 Italian infectious disease centers.
  • Anonymous data from 3,760 HBsAg-positive patients aged ≥18 years were collected between February and July 2008.

Main Results:

  • Immigrants constituted 24.8% of HBsAg-positive subjects, primarily from the Far East and Eastern Europe.
  • Migrants were younger, more often female, and more frequently HBeAg-positive than Italian carriers.
  • Migrants showed different HBV genotypes, higher rates of inactive carriers, and lower prevalence of cirrhosis and HCC, with significantly less access to antiviral treatment.

Conclusions:

  • Immigrants comprise a significant portion of HBV carriers in Italian centers, exhibiting unique demographic and virological features.
  • Migrant HBV carriers demonstrate poorer access to antiviral treatment compared to native Italian carriers.