Related Experiment Video
Updated: May 15, 2026

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
Cyclofenil as a possible cause of non-arteritic anterior ischaemic optic neuropathy
Benjamin Clarke1, Evripidis Sykakis, Dipak N Parmar
1Department of Ophthalmology, Whipps Cross University Hospital, London, UK. esykakis@gmail.com
Abstract:
A 27-year-old woman receiving the steroid drug cyclofenil as a fertility adjunct, experienced blurred vision 24 h after missing a dose and taking a double dose to 'catch up' with her therapeutic protocol. She was found to have a non-arteritic anterior ischaemic optic neuropathy with a visual hemifield defect and impaired optic nerve function, which has not since shown any recovery. This case highlights the prothrombotic potential for the drug when used above normal dosing range, and is therefore of great guidance for those initiating it as a fertility treatment, or in unlicensed use.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
Photoreceptors and Visual Pathways
Diabetic Retinopathy
