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Updated: May 15, 2026

Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
Published on: May 26, 2023
Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation
Claas T Buschmann1, Werner Stenzel, Hubert Martin
1Institute of Legal Medicine and Forensic Sciences, Charité, Universitätsmedizin Berlin, Turmstr. 21, Building N, 10559, Berlin, Germany, claas.buschmann@charite.de.
Abstract:
We report three autopsy cases of wide-spread myocardial necrosis with calcification in pediatric patients after temporary generalized hypoxia and initially successful cardiopulmonary resuscitation, but subsequent in-hospital death. Autopsy and histological workup in all three cases showed multiple circumscribed calcified and necrotic areas in progressive stages of organization within the myocardium. We conclude that these macro- and microscopic autopsy features appear to be related to reperfusion injuries in children as a consequence of hypoxic-ischemic changes occurring in the peri- and postresuscitation period.
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