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Overcoming matrix effects: GC method development for the determination of triethylamine and dimethyl sulfoxide in a
Jingzhi Tian1, Guoru Chen, Zhangfei He
1Merial Limited, Analytical R&D, 631 US Route 1 South, North Brunswick, NJ 08902.
Abstract:
A direct injection gas chromatography method was developed for the determination of triethylamine and dimethyl sulfoxide (DMSO) in a drug substance (ML-189). Matrix effects were found to result in the overestimation of DMSO when methanol was used as diluent. Multiple approaches to eliminate matrix effects were unsuccessful; these included changes in sample size, split ratio, injector temperature and injector liner (e.g., deactivated liner). Ultimately, matrix effects were eliminated after the diluent was changed from methanol to acetone. A mechanism was proposed and discussed.
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