Related Experiment Video

Updated: May 15, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Echocardiographic assessment of inappropriate left ventricular mass and left ventricular hypertrophy in patients with

Hasan Shemirani1, Rohola Hemmati, Alireza Khosravi

  • 1Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|December 25, 2012
PubMed

Insights

Left ventricular hypertrophy (LVH) correlates with diastolic dysfunction severity. However, inappropriate left ventricular mass (LVM) only slightly predicts diastolic dysfunction in hypertension patients.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Hypertension Research

Background:

  • Early detection of left ventricular mass (LVM) inappropriateness and left ventricular hypertrophy (LVH) is crucial for preventing diastolic left ventricular dysfunction.
  • Diastolic dysfunction is a significant contributor to cardiovascular morbidity and mortality.

Purpose of the Study:

  • To investigate the association between left ventricular hypertrophy (LVH) and diastolic dysfunction.
  • To determine if inappropriate left ventricular mass (LVM) is linked to diastolic dysfunction in hypertensive individuals.

Main Methods:

  • 125 patients with uncomplicated hypertension underwent two-dimensional echocardiography.
  • Inappropriate LVM and LVH were defined using established criteria based on gender-specific indices and wall thickness.
  • Echocardiographic parameters including E/A ratio, deceleration time (DT), and E/E' were measured.

Main Results:

  • 21.7% of subjects exhibited inappropriate LV mass, with 5.6% having moderate and 5.6% severe abnormalities.
  • Moderate and severe LVH were associated with higher age and BMI.
  • LVH severity correlated with E/A ratio and DT, but inappropriate LVM showed only a slight, non-significant association with diastolic dysfunction parameters.

Conclusions:

  • Left ventricular hypertrophy (LVH) is significantly correlated with the severity of diastolic dysfunction, as indicated by E/A ratio and deceleration time.
  • Inappropriate left ventricular mass (LVM) demonstrates a limited predictive capacity for diastolic dysfunction severity in uncomplicated hypertension.
Abstract

Keywords:
Diastolic dysfunctionEchocardiographicleft ventricular hypertrophyleft ventricular mass

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.