Related Experiment Video
Updated: May 15, 2026
08:43
A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
Published on: March 10, 2017
Omics Screening for Pharmaceutical Efficacy and Safety in Clinical Practice
Andrew A Monte1, Vasilis Vasiliou, Kennon J Heard
1Rocky Mountain Poison and Drug Center, Denver, CO, USA ; University of Colorado School of Medicine, Department of Emergency Medicine Aurora, CO, USA.
Journal of Pharmacogenomics & Pharmacoproteomics
|December 25, 2012
Summary
The
Area of Science:
- Pharmacogenomics
- Clinical Diagnostics
Background:
- Advancements in molecular techniques enable trait association with genomic, epigenomic, transcriptomic, proteomic, and metabolomic polymorphisms.
- The 'omics era has integrated screening assays for pharmaceutical efficacy and safety into clinical practice.
Purpose of the Study:
- To discuss each 'omic field and available screening assays for clinicians.
- To highlight challenges and future directions for 'omic integration in pharmaceutical therapy.
Main Methods:
- Review of genomic, epigenomic, transcriptomic, proteomic, and metabolomic screening assays.
- Discussion of current clinical applications and limitations of 'omic technologies.
Main Results:
- Success has been demonstrated across various 'omic fields in improving pharmaceutical outcomes.
- Significant challenges persist, including limited assay availability, low predictive values, and high costs.
Conclusions:
- Wider assay availability, improved predictive accuracy, and cost reduction are crucial for clinical adoption.
- Further development of techniques, combined 'omic assays, and increased clinical utilization are necessary for realizing the full potential of 'omic screens in pharmaceutical therapy.
Related Concept Videos
01:19Pharmacovigilance
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
02:46Genetic Screens
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...