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Updated: May 15, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?
Yann Godet1, Magalie Dosset, Christophe Borg
1INSERM U1098; Unité Mixte de Recherche; Besançon, France ; Etablissement Français du Sang de Bourgogne Franche-Comté; Besançon, France ; Université de Franche-Comté; Besançon, France.
Abstract:
Insights into antitumor T-cell responses may help the development of more efficient treatments for lung cancer. The interplay between preexisting antitumor CD4(+) T-cell responses and platinum-based chemotherapy is crucial to improve patient survival. Accumulating evidence confirms that selecting cancer patients in whom chemotherapy can activate an anticancer immune response would largely improve the success of novel therapeutic approaches.
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