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Related Experiment Video

Updated: May 15, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Biodentine used as a pulp-capping agent in primary pig teeth.

Amir Shayegan1, Cédric Jurysta, Ramin Atash

  • 1Queen Fabiola Children's University Hospital, Department of Pediatric Dentistry, Free University of Brussels, Brussels, Belgium. shayegan_amir@hotmail.com

Pediatric Dentistry
|December 26, 2012
PubMed
Summary

Biodentine and white mineral trioxide aggregate (WMTA) show promising results for primary tooth pulp treatments. Both materials demonstrated suitability and biocompatibility in pulpotomy and direct pulp capping procedures in pigs.

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Area of Science:

  • Biomaterials Science
  • Pediatric Dentistry
  • Dental Histology

Background:

  • Assessing biocompatible materials for vital pulp therapy in primary teeth is crucial for maintaining tooth structure and function.
  • Traditional materials like formocresol raise concerns regarding toxicity and long-term effects.

Purpose of the Study:

  • To compare the pulp response in primary pig teeth following pulpotomy and direct pulp capping with Biodentine, white mineral trioxide aggregate (WMTA), and formocresol (FC) or calcium hydroxide.
  • To evaluate the histological outcomes and hard tissue formation associated with these biomaterials.

Main Methods:

  • 180 primary pig teeth were treated with Biodentine, WMTA, or FC for pulpotomy, and Biodentine, WMTA, or calcium hydroxide for direct pulp capping.
  • Histological examinations were performed at 7, 28, and 90 days post-treatment.

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Last Updated: May 15, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

  • Statistical analysis included Kruskal-Wallis and Dunn tests.

    • Main Results:

    • Pulpotomy groups showed significant differences in inflammatory response and hard tissue formation between Biodentine/WMTA and FC.
    • Direct pulp capping groups exhibited a significant difference in hard tissue formation between Biodentine and calcium hydroxide at 7 days.

    Conclusions:

    • Biodentine and WMTA are suitable and biocompatible materials for pulp capping in primary teeth.
    • These findings support the use of Biodentine and WMTA as alternatives to traditional materials in pediatric endodontics.