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Related Concept Videos

Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...

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Related Experiment Video

Updated: May 15, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Hypophosphatemia in critically ill patients.

Satoshi Suzuki1, Moritoki Egi, Antoine G Schneider

  • 1Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.

Journal of Critical Care
|December 26, 2012
PubMed
Summary

Hypophosphatemia in critically ill patients is linked to higher mortality but is not an independent predictor. It serves as a marker of illness severity rather than a direct cause of death.

Keywords:
Critical illnessHypophosphatemiaInorganic phosphateIntensive care unitMortality

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: May 2, 2017

Area of Science:

  • Critical Care Medicine
  • Clinical Chemistry
  • Epidemiology

Background:

  • Phosphate levels are crucial for cellular function.
  • Electrolyte imbalances, including hypophosphatemia, are common in critically ill patients.
  • The independent prognostic value of hypophosphatemia in intensive care unit (ICU) settings requires further clarification.

Purpose of the Study:

  • To investigate the association between phosphate concentration and clinical outcomes in critically ill patients.
  • To determine if hypophosphatemia is an independent predictor of mortality in this population.

Main Methods:

  • Retrospective observational study of 2730 adult patients in an Australian general ICU.
  • Analysis of 10504 phosphate measurements.
  • Multivariable logistic regression to assess independent predictors of mortality.

Main Results:

  • Hypophosphatemia (iP ≤ 0.6 mmol/L) occurred in 20% of patients.
  • Patients with hypophosphatemia showed higher ICU mortality (P = .004) and lower minimum phosphate concentrations (P = .009) compared to survivors.
  • However, hypophosphatemia was not an independent risk factor for ICU or hospital mortality after multivariable analysis (P > .20).

Conclusions:

  • Hypophosphatemia in critically ill patients is associated with increased mortality.
  • It functions as a marker of illness severity, not an independent predictor of mortality.
  • The timing, duration, and varying definitions of hypophosphatemia did not alter its lack of independent predictive value.