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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

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Published on: February 27, 2018

Epigenetics as a new therapeutic target for postoperative cognitive dysfunction.

Yun Wang1, Zhijun Chen, Yujie Zhao

  • 1Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Medical Hypotheses
|December 26, 2012
PubMed
Summary

Postoperative cognitive disorder (POCD) may stem from epigenetic dysregulation, a potential common pathway for known risk factors. This hypothesis suggests epigenetic interventions could treat POCD and its associated memory and learning impairments.

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Postoperative cognitive disorder (POCD) is characterized by persistent memory and learning disabilities.
  • Risk factors for POCD include general anesthesia, hypotension, hypoxia, and surgical stress.
  • Epigenetic dysregulation is linked to abnormal brain function and neurodegenerative diseases.

Purpose of the Study:

  • To hypothesize that epigenetic dysregulation is a critical mechanism underlying POCD.
  • To propose epigenetic intervention as a novel therapeutic strategy for POCD.

Main Methods:

  • Review of current evidence linking POCD risk factors to epigenetic changes.
  • Hypothesis formulation based on the role of chromatin remodeling in memory-associated gene expression.

Main Results:

  • Risk factors for POCD may induce epigenetic dysfunction in the brain.
  • Epigenetic regulation, particularly chromatin remodeling, is essential for memory-associated gene transcription.

Conclusions:

  • Epigenetic dysregulation is hypothesized as a central mechanism in POCD.
  • This hypothesis opens avenues for developing targeted epigenetic therapies for POCD.