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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: May 15, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

Gene therapy for the inner ear.

Hideto Fukui1, Yehoash Raphael

  • 1Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Dr., Ann Arbor, MI 48109-5648, USA.

Hearing Research
|December 26, 2012
PubMed
Summary

Gene therapy offers hope for inner ear diseases by targeting molecular pathways. Researchers are exploring gene vectors for safe and effective delivery to regenerate auditory and balance systems.

Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Gene Therapy

Background:

  • Animal studies reveal molecular pathways for inner ear development, repair, and regeneration.
  • Transgenic mouse models have identified key genes for hair cell development and regeneration.
  • Current limitations prevent direct application of mouse models to human inner ear treatment.

Purpose of the Study:

  • To review gene vectors suitable for inner ear gene therapy.
  • To discuss practical methods for vector delivery to the inner ear.
  • To assess the progress and future needs for clinical application of gene transfer therapies.

Main Methods:

  • Review of gene vectors for inner ear gene therapy.
  • Discussion of practical aspects of vector introduction into the ear.

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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

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Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
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Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
07:32

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

  • Analysis of progress in gene transfer for auditory and balance systems.

    • Main Results:

    • Several gene vectors are identified as potentially useful for inner ear gene therapy.
    • Practical considerations for delivering these vectors to the inner ear are outlined.
    • Progress in gene transfer for both auditory and balance systems is reviewed.

    Conclusions:

    • Gene therapy holds promise for treating inner ear diseases.
    • Development of effective gene vectors and delivery methods is crucial.
    • Further technological advancements are required for clinical translation.