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Related Experiment Video

Updated: May 15, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Functional connectivity changes in patients with absence epilepsy studied using resting-state functional MRI.

Tie Fang¹, Fang Fang, Hongwei Zhu

¹Beijing Functional Neurosurgery Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. victorft369@yahoo.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|December 26, 2012

Summary

Functional connectivity alterations in absence epilepsy were identified using resting-state fMRI. Patients showed changes in brain network connections, particularly in the superior frontal gyrus, impacting epilepsy development.

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Last Updated: May 15, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

Neuroscience
Epilepsy Research
Brain Imaging

Background:

Altered functional connectivity is a hallmark of various mental disorders.
Understanding these alterations is crucial for diagnosing and treating neurological conditions.

Purpose of the Study:

To investigate changes in functional brain connectivity in patients with absence epilepsy.
To identify specific brain regions and network alterations associated with absence epilepsy.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was employed.
Analysis focused on functional connectivity within and between brain modules.

Main Results:

Patients with absence epilepsy exhibited altered functional connectivity within and between brain modules.
An increase in positive and decrease in negative connections were observed.
The superior frontal gyrus showed altered connectivity with the frontal default mode network and limbic system.

Conclusions:

Findings suggest that the balance of functional connections within and between brain modules plays a role in absence epilepsy.
This research offers new insights into the neurobiological underpinnings of absence epilepsy.