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Updated: May 15, 2026
10:41
A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
Published on: April 30, 2020
[Acute miliary tuberculosis or Isambert disease: a case report].
1Service d'ORL et chirurgie cervico-faciale, CHU Mohammed VI, Marrakech, Maroc. ziad.tarik.orl@gmail.com
Summary
Pharyngeal tuberculosis, a rare but increasing infection, presents as throat lesions from Mycobacterium tuberculosis. Early diagnosis and antituberculous chemotherapy are crucial for favorable outcomes in head and neck cases.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Pediatrics
Background:
- Pharyngeal tuberculosis involves active, granulomatous lesions in the pharyngeal mucosa caused by Mycobacterium tuberculosis.
- An upsurge in tuberculosis cases necessitates considering pharyngeal involvement in endemic regions, especially with head and neck symptoms.
Observation:
- A 9-year-old girl presented with dysphagia, pharyngeal discomfort, snoring, and hoarseness for 8 months, indicative of a pharyngeal syndrome.
- Clinical examination revealed diffuse oropharyngeal mucosal granulation, accompanied by an impaired general condition.
- Diagnostic workup identified an inflammatory syndrome, a strongly positive intradermal tuberculin reaction, and a biopsy showing giant cell granuloma with caseous necrosis.
Findings:
- The case highlights acute miliary tuberculosis manifesting as pharyngeal lesions.
- Histopathological analysis confirmed granulomatous inflammation with caseous necrosis, characteristic of tuberculosis.
- The patient's condition improved significantly with antituberculous chemotherapy.
Implications:
- This case underscores the importance of suspecting pharyngeal tuberculosis in endemic areas, particularly with persistent head and neck symptoms.
- Prompt diagnosis through clinical evaluation, tuberculin testing, and biopsy is essential.
- Effective antituberculous chemotherapy leads to favorable outcomes, emphasizing the treatability of this rare condition.
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