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Related Experiment Video

Updated: May 15, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Excessively elevated C-reactive protein after surgery for temporal lobe epilepsy.

Christoph M Woernle1, Marian C Neidert, Marie-Angela Wulf

  • 1Department of Neurosurgery, University Hospital Zurich, Frauenklinikstr. 10, CH-8091 Zurich, Switzerland. c.woernle@gmail.com

Clinical Neurology and Neurosurgery
|December 26, 2012
PubMed
Summary

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Patients undergoing anteromesial temporal lobe resection for epilepsy experienced excellent seizure control. Post-surgery, C-reactive protein (CRP) levels were significantly elevated, indicating a potential inflammatory response unrelated to infection.

Area of Science:

  • Neurosurgery
  • Epileptology
  • Clinical Chemistry

Background:

  • Temporal lobe epilepsy (TLE) is a common neurological disorder often treated with surgery.
  • Anteromesial temporal lobe resection is a surgical option for refractory TLE.
  • Elevated C-reactive protein (CRP) levels can indicate inflammation, but their role after epilepsy surgery is not fully understood.

Purpose of the Study:

  • To evaluate seizure outcomes after anteromesial temporal lobe resection for TLE.
  • To investigate C-reactive protein (CRP) levels in patients following temporal lobe epilepsy surgery.
  • To compare CRP levels in epilepsy surgery patients with those undergoing surgery for supratentorial tumors.

Main Methods:

  • Retrospective analysis of 87 patients who underwent anteromesial temporal lobe resection for TLE.
Keywords:
AmygdalohippocampectomyC-reactive proteinCircumventricular organsNeurosurgerySeizure outcomeTherapy refractory epilepsy

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  • Seizure outcome classified using the International League Against Epilepsy (ILAE) scale.
  • CRP levels measured in 59 epilepsy patients and compared to 44 control patients with supratentorial tumors.

    • Main Results:

    • Excellent clinical benefit (96.6%) and seizure freedom (80.5%) were achieved post-surgery.
    • Significantly higher postoperative CRP peak levels were observed in the TLE group (100.86 mg/l) compared to the control group (36.85 mg/l) (p<0.001).
    • A weak correlation was found between CRP levels and peak temperature (r=0.31).

    Conclusions:

    • Anteromesial temporal lobe resection provides excellent seizure control for refractory TLE.
    • Elevated CRP levels are common after temporal lobe epilepsy surgery, even without clinical infection.
    • Postoperative CRP elevation in TLE patients is significantly higher than in patients undergoing resection for other supratentorial lesions.