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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Related Experiment Video

Updated: May 15, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

Antimicrobial compounds from Alpinia conchigera.

Ahmad Nazif Aziz1, Halijah Ibrahim, Devi Rosmy Syamsir

  • 1Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu (UMT), 21030 Kuala Terengganu, Terengganu, Malaysia.

Journal of Ethnopharmacology
|December 26, 2012
PubMed
Summary
This summary is machine-generated.

Alpinia conchigera rhizome extracts show potent antimicrobial activity against fungi and Staphylococcus aureus, validating traditional medicinal uses for skin infections. This study identified key compounds responsible for these effects.

Related Experiment Videos

Last Updated: May 15, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

Area of Science:

  • Phytochemistry
  • Microbiology
  • Ethnobotany

Background:

  • Alpinia conchigera rhizome is traditionally used for fungal infections and as a postpartum medicine in Malaysia.
  • The plant's young shoots are also consumed as a vegetable dish.

Purpose of the Study:

  • To investigate the chemical constituents of Malaysian Alpinia conchigera pseudostems and rhizomes.
  • To evaluate the antimicrobial activity of plant extracts and isolated compounds against fungi and Staphylococcus aureus strains.

Main Methods:

  • Soxhlet extraction of pseudostems and rhizomes using n-hexane, dichloromethane (DCM), and methanol.
  • Column chromatography for isolation and purification of compounds.
  • Determination of minimum inhibitory concentration (MIC) against Candida albicans, dermatophytes, and Staphylococcus aureus.

Main Results:

  • DCM extract of Alpinia conchigera rhizome exhibited potent antifungal activity against Candida albicans, Microsporum canis, and Trycophyton rubrum.
  • Significant inhibitory activity was observed against MSSA, MRSA, and Sa7 strains of Staphylococcus aureus.
  • Isolated compounds like 1'S-1'-acetoxyeugenol, trans-p-coumaryl diacetate, and p-hydroxycinnamyl acetate showed varying degrees of antimicrobial activity.

Conclusions:

  • The study confirms the traditional use of Alpinia conchigera rhizome for treating skin infections.
  • The observed antibacterial, anticandidal, and antidermatophyte activities support its ethnopharmacological relevance.