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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

CD146, a multi-functional molecule beyond adhesion.

Zhaoqing Wang1, Xiyun Yan

  • 1Protein and Peptide Pharmaceutical Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, People's Republic of China. clairezqwang@hotmail.com

Cancer Letters
|December 26, 2012
PubMed
Summary
This summary is machine-generated.

CD146, a cell adhesion molecule, plays roles beyond cell adhesion, including in cancer and angiogenesis. This review explores its diverse functions and mechanisms, highlighting its importance as a novel biomarker.

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Last Updated: May 15, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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Published on: October 17, 2014

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • CD146 (Melanoma Cell Adhesion Molecule) is a cell adhesion molecule (CAM) found at endothelial cell junctions.
  • Initially identified as a melanoma tumor marker, CD146's role extends beyond cell adhesion.
  • Emerging research reveals CD146's involvement in development, signaling, cell migration, stem cell differentiation, angiogenesis, and immune responses.

Purpose of the Study:

  • To review the dynamic research surrounding CD146.
  • To highlight newly identified functions of CD146.
  • To elucidate the underlying mechanisms of CD146's diverse roles.

Main Methods:

  • Literature review of recent studies on CD146.
  • Analysis of experimental data on CD146 functions.
  • Synthesis of current understanding of CD146 mechanisms.

Main Results:

  • CD146 is implicated in various biological processes beyond its initial identification.
  • CD146 is recognized as a significant biomarker for angiogenesis and cancer.
  • Novel functions and mechanisms of CD146 are continually being uncovered.

Conclusions:

  • CD146 is a multifaceted molecule with critical roles in numerous physiological and pathological processes.
  • Further research into CD146 mechanisms will enhance its utility as a biomarker.
  • CD146 represents a promising target for therapeutic interventions in cancer and angiogenesis-related diseases.