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CD146, a multi-functional molecule beyond adhesion

Zhaoqing Wang1, Xiyun Yan

  • 1Protein and Peptide Pharmaceutical Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, People's Republic of China. clairezqwang@hotmail.com

Cancer Letters
|December 26, 2012
PubMed

Insights

CD146, a cell adhesion molecule, plays roles beyond cell adhesion, including in cancer and angiogenesis. This review explores its diverse functions and mechanisms, highlighting its importance as a novel biomarker.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • CD146 (Melanoma Cell Adhesion Molecule) is a cell adhesion molecule (CAM) found at endothelial cell junctions.
  • Initially identified as a melanoma tumor marker, CD146's role extends beyond cell adhesion.
  • Emerging research reveals CD146's involvement in development, signaling, cell migration, stem cell differentiation, angiogenesis, and immune responses.

Purpose of the Study:

  • To review the dynamic research surrounding CD146.
  • To highlight newly identified functions of CD146.
  • To elucidate the underlying mechanisms of CD146's diverse roles.

Main Methods:

  • Literature review of recent studies on CD146.
  • Analysis of experimental data on CD146 functions.
  • Synthesis of current understanding of CD146 mechanisms.

Main Results:

  • CD146 is implicated in various biological processes beyond its initial identification.
  • CD146 is recognized as a significant biomarker for angiogenesis and cancer.
  • Novel functions and mechanisms of CD146 are continually being uncovered.

Conclusions:

  • CD146 is a multifaceted molecule with critical roles in numerous physiological and pathological processes.
  • Further research into CD146 mechanisms will enhance its utility as a biomarker.
  • CD146 represents a promising target for therapeutic interventions in cancer and angiogenesis-related diseases.

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