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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Effect of HCV infection on cause-specific mortality after HIV seroconversion, before and after 1997
Jannie van der Helm1, Ronald Geskus, Caroline Sabin
1Public Health Service Amsterdam, Amsterdam, the Netherlands. jvdhelm@ggd.amsterdam.nl
Gastroenterology
|December 26, 2012
Summary
Individuals with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection face higher mortality risks from HIV/AIDS and liver disease. This increased risk persists even after combination antiretroviral therapy became widely available.
Area of Science:
- Infectious Diseases
- Hepatology
- Epidemiology
Background:
- Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection is common.
- The impact of HCV co-infection on HIV disease progression and mortality remains incompletely understood.
Purpose of the Study:
- To determine the effect of HCV co-infection on mortality from HIV/AIDS and hepatitis/liver disease.
- To adjust for the duration of HIV infection in the analysis.
Main Methods:
- Analysis of data from the Concerted Action on Seroconversion to AIDS and Death in Europe (CASCADE) collaboration.
- Utilized a competing-risks proportional subdistribution hazards model.
- Evaluated mortality from HIV/AIDS-related, hepatitis/liver-related, natural, and non-natural causes.
Main Results:
- After 1997, mortality from HIV/AIDS and liver disease decreased for both HIV-only and co-infected individuals.
- However, HIV/AIDS-related mortality remained higher in co-infected individuals across various risk groups.
- Co-infected individuals exhibited a higher risk of death from hepatitis or liver disease compared to HIV-only individuals.
Conclusions:
- Since 1997, HIV/HCV co-infected individuals have a greater risk of death from HIV/AIDS and liver disease than those with HIV alone.
- The findings underscore the need to evaluate the impact of HCV therapy on HIV progression.
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