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Related Experiment Video

Updated: May 15, 2026

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Neuropeptide GPCRs in C. elegans.

Lotte Frooninckx¹, Liesbeth Van Rompay, Liesbet Temmerman

¹Laboratory of Functional Genomics and Proteomics, Department of Biology, Katholieke Universiteit Leuven Leuven, Belgium.

Frontiers in Endocrinology

|December 26, 2012

Summary

This summary is machine-generated.

Neuropeptidergic signaling in Caenorhabditis elegans is crucial for behavior. This review details known and predicted neuropeptide G protein-coupled receptors (GPCRs), advancing our understanding of this signaling network.

Keywords:

Caenorhabditis elegans G protein-coupled receptor GPCR deorphanization nematoda neuropeptidergic signaling

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Area of Science:

Neuroscience
Molecular Biology
Genomics

Background:

Neuropeptidergic signaling is vital for most organisms, including the nematode Caenorhabditis elegans.
C. elegans serves as an excellent model for studying neuropeptidergic signaling at single-cell resolution due to advanced genetic tools and a fully sequenced genome.

Purpose of the Study:

To review the current state of verified and predicted neuropeptide G protein-coupled receptors (GPCRs) in C. elegans.
To discuss the classification and deorphanization of these receptors.
To highlight the role of neuropeptides and GPCRs in C. elegans behavioral variability.

Main Methods:

Genome-wide analysis to identify putative neuropeptides and their cognate G protein-coupled receptors (GPCRs).
Classification of predicted GPCRs based on homology to insect and vertebrate orthologs.
Application of deorphanization strategies to identify natural ligands for predicted GPCRs.
Integration of localization and functional studies to understand signaling pathways.

Main Results:

Compilation of verified and predicted neuropeptide GPCRs in C. elegans.
Development and application of deorphanization strategies have significantly expanded knowledge of neuropeptidergic signaling.
Functional characterization of numerous neuropeptidergic signaling pathways.

Conclusions:

Neuropeptides and their GPCRs are key regulators of behavioral variability in C. elegans.
Continued research into neuropeptidergic signaling pathways offers potential for understanding complex behaviors.
This review provides a comprehensive overview of C. elegans neuropeptide GPCRs and their functional significance.