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Updated: May 15, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
Published on: April 26, 2024
Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
Brendan E Russ1, Alice E Denton, Lauren Hatton
1Department of Microbiology and Immunology, University of Melbourne Parkville, VIC, Australia.
Abstract:
A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.
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