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Development of acute dystonia in three brothers due to metoclopramide

Ibrahim Silfeler1, Vefik Arica, Secil Arica

  • 1Department of Pediatrics, School of Medicine, Mustafa Kemal University, Hatay, Turkey.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|December 26, 2012
PubMed

Insights

Metoclopramide can cause acute dystonic reactions. In one family, three brothers experienced this adverse drug reaction after metoclopramide treatment, suggesting a potential genetic predisposition.

Area of Science:

  • Neurology
  • Pharmacology
  • Genetics

Background:

  • Metoclopramide is a commonly prescribed medication for gastrointestinal issues.
  • Dystonic reactions are a known, albeit uncommon, side effect of metoclopramide.
  • Family history can play a role in adverse drug reactions.

Observation:

  • Three brothers from the same family developed acute dystonic reactions shortly after receiving their first dose of metoclopramide.
  • The patients were treated with metoclopramide for gastroenteritis.
  • Symptoms of acute dystonia appeared within 30 minutes of medication administration.

Findings:

  • The simultaneous occurrence of acute dystonic reactions in multiple siblings treated with metoclopramide suggests a potential familial susceptibility.
  • This case highlights a possible genetic link or shared environmental factor influencing metoclopramide-induced dystonia.

Implications:

  • Healthcare providers should consider metoclopramide's risk of dystonic reactions, especially in patients with a family history.
  • If one family member experiences a metoclopramide-induced dystonic reaction, caution is advised when prescribing it to other family members.
  • Further research into the genetic factors influencing metoclopramide pharmacodynamics may be warranted.
Keywords:
Dystonic reactionmedicine side effectsmetoclopramide

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