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Updated: May 15, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
Matrix isolation of the elusive fluorocarbonylsulfenyl fluoride molecule FC(O)SF
Melina V Cozzarín1, Rosana M Romano, Helge Willner
1CEQUINOR (UNLP-CONICET), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 esq. 115, (1900) La Plata, Argentina.
Abstract:
The syn and anti conformers of the hitherto unknown fluorocarbonylsulphenyl fluoride FC(O)SF were formed through the photochemical reactions between OCS and F(2), isolated in solid Ar. The reactions were followed by Fourier transform infrared (FTIR) spectroscopy, and the unknown products were proposed by comparison of the observed IR absorptions with their computed IR spectra. The reactions occur through a 1:1 molecular complex between OCS and F(2), forming the anti-FC(O)SF first, which subsequently transforms into the syn form, through a randomization process. At longer times of irradiation, FC(O)SF decomposes by extrusion of a CO molecule with the concomitant formation of SF(2) and the formation of a difluorophosgene molecule, O═CF(2). The migration of fluorine atoms in the matrixes is proposed to explain the formation of SF(4) and SF(6).
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