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Updated: May 15, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Experience of pediatric stroke from a tertiary medical center in North India
Jayantee Kalita1, Gourav Goyal, Usha Kant Misra
1Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
Insights
Pediatric stroke in Northern India is most commonly arterial ischemic stroke (AIS), often caused by infections. Level of consciousness on admission predicted mortality in these stroke cases.
Area of Science:
- Neurology
- Pediatrics
- Public Health
Background:
- Pediatric stroke etiology and outcomes vary globally.
- Limited comprehensive data exists for pediatric stroke in India.
- This study addresses the gap by analyzing cases from Northern India.
Purpose of the Study:
- To evaluate the causes, types, and outcome predictors of pediatric stroke in Northern India.
- To provide region-specific data on pediatric stroke epidemiology.
Main Methods:
- Retrospective analysis of 79 pediatric stroke patients (1 month to 18 years) from 2001-2011.
- Data collected included clinical, imaging, laboratory findings, and stroke risk factors.
- Multivariate analysis identified predictors of mortality.
Main Results:
- Arterial ischemic stroke (AIS) was the most common type (78.5%), followed by intracerebral hemorrhage (ICH) (12.7%) and cerebral venous sinus thrombosis (CVST) (8.9%).
- Neuroinfections were the leading cause (31.6%), followed by cardioembolic sources (11.4%) and cryptogenic strokes (16.5%).
- Mortality was 8.9%, with the level of consciousness on admission identified as a significant predictor of death.
Conclusions:
- AIS is more prevalent than ICH in this Northern Indian cohort.
- Infections represent a significant and potentially preventable cause of pediatric stroke in the region.
- Early assessment of consciousness level is crucial for predicting outcomes in pediatric stroke.
Objective:
The etiology and outcome of pediatric stroke differs in different geographical regions and there is no comprehensive study from India. This study evaluates the etiology, type and predictors of outcome of pediatric stroke from Northern India.
Methods:
79 stroke patients aged 1month to 18years managed during 2001-2011 were retrospectively analyzed. Their mean age was 144.8months (0.6-18years) and 26 were females. Detailed history including stroke risk factors was noted. The clinical, imaging and laboratory findings were recorded. Stroke was classified as per neuroimaging findings. The predictors of death were evaluated by multivariate analysis.
Results:
62 (78.5%) patients had arterial ischemic stroke (AIS), 10 (12.7%) intracerebral hemorrhage (ICH) and 7 (8.9%) had cerebral venous sinus thrombosis (CVST). The underlying etiology was neuroinfections in 25, cardioembolic in 9, prothrombotic conditions in 5, arteriopathy in 4, arterial dissection in 3, mitochondrial cytopathy and cervical rib in 1 each and cryptogenic in 13 patients. 7 patients died. On multivariate analysis death was related to level of consciousness on admission.
Conclusion:
AIS is more common than ICH in this study and 8.9% patients died. Infection is the most common cause of pediatric stroke in Northern India which is amenable to therapy and is preventable.
Related Concept Videos
Stroke: Introduction and Types
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Ischemic Stroke l: Introduction
Transient Ischemic Attack l: Introduction

