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Updated: May 15, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Squamous cell carcinoma in bladder exstrophy: a rare entity.

Sachin Patil¹, Sudhir Kumar Jain, Ramchandra Kaza

¹Department of Surgery, Saint Barnabas Medical Center, NJ 07039, USA. drpatil_sachin@yahoo.co.in

Singapore Medical Journal

|December 27, 2012

Summary

This summary is machine-generated.

Carcinomas of the exstrophic urinary bladder are rare. Regular cystoscopy surveillance after primary closure can improve outcomes for these rare bladder cancer cases.

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Area of Science:

Urology
Oncology

Background:

Carcinomas arising from an exstrophic urinary bladder are rare, with only seven cases previously reported.
This study presents the eighth case of advanced squamous cell carcinoma originating from an exstrophic bladder.

Observation:

The study reviewed eight cases, with a mean patient age of 54.9 years and a male to female ratio of 3:1.
The average symptom duration was 18.6 months, with new growth being the most common symptom.
Disease stages varied, with most patients presenting with advanced disease.

Findings:

Five of the eight patients underwent surgery.
Four patients in the treatment group achieved disease-free status.
The mean survival period for treated patients was 30 months.

Implications:

The findings underscore the rarity of exstrophic bladder carcinoma.
Regular surveillance with cystoscopy is recommended for patients with a history of primary closure of exstrophic bladder.
Early detection and surgical intervention may improve survival rates for this rare malignancy.