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Updated: May 15, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Livedoid vasculopathy and its association with factor V Leiden mutation
Angeline Anning Yong1, Audrey Wei Hsia Tan, Yoke Chin Giam
1National Skin Centre, Singapore. angelpeace109@hotmail.com
Singapore Medical Journal
|December 27, 2012
Summary
Livedoid vasculopathy, a leg ulcer disorder, may be linked to factor V Leiden mutation in Indian patients. Treatment involved immunosuppressants, pentoxifylline, and antiplatelets for remission.
Area of Science:
- Vascular Medicine
- Genetics
Background:
- Livedoid vasculopathy is a rare, chronic disorder causing painful leg ulcers.
- It involves thrombosis and vasculitis, often with unknown triggers.
Observation:
- Two Indian women presented with livedoid vasculopathy.
- Both cases were associated with heterozygous factor V Leiden mutation.
- No other thrombotic events were noted; livedoid vasculopathy was the sole manifestation.
Findings:
- Factor V Leiden mutation, a prothrombotic disorder, was identified in patients with livedoid vasculopathy.
- Initial immunosuppressive therapy was insufficient; pentoxifylline and antiplatelets were key to remission.
- The association, though uncommon, is significant in Indian populations due to higher factor V Leiden prevalence.
Implications:
- Highlights the importance of screening for prothrombotic disorders like factor V Leiden in livedoid vasculopathy patients, especially in Indian ethnicities.
- Suggests a combined treatment approach including anticoagulation/antiplatelet therapy alongside immunosuppression for effective management.
- Underscores ethnic variations in genetic predisposition to thrombotic disorders.
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