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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

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Related Experiment Video

Updated: May 15, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Gene therapy for psychiatric disorders.

Yaroslav Gelfand1, Michael G Kaplitt

  • 1Laboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA.

World Neurosurgery
|December 27, 2012
PubMed
Summary

Gene therapy is emerging for psychiatric disorders, leveraging deep brain stimulation techniques. Neurosurgeons are poised to lead advancements in treating conditions like depression and schizophrenia.

Keywords:
5-HT5-HydroxytryptamineAAVAddictionAdeno-associated virusArea 25BDNFBrain-derived neurotrophic factorCNSCPPCentral nervous systemConditioned place preferenceDISC1DepressionDisrupted In Schizophrenia-1FSTForced swim testGene therapyInfralimbic cortexKOKnockoutNAccNucleus accumbensOCDObsessive-compulsive disorderPDParkinson diseaseSRFSerum response factorSmall interfering RNATSTTail suspension testp11siRNA

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Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
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Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

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Last Updated: May 15, 2026

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06:59

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Published on: May 21, 2020

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
08:37

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Area of Science:

  • Neurosurgery
  • Psychiatry
  • Gene Therapy

Background:

  • Gene therapy shows promise for neurological disorders like Parkinson's and Alzheimer's.
  • Deep brain stimulation is increasingly used for refractory psychiatric conditions.
  • Advancements in understanding brain circuitry fuel psychiatric treatment development.

Purpose of the Study:

  • To review the current status of gene therapy for psychiatric disorders.
  • To highlight promising research areas for psychiatric gene therapy.
  • To discuss challenges unique to psychiatric gene therapy.

Main Methods:

  • Review of current literature on gene therapy for psychiatric disorders.
  • Focus on research applicable to human trials for depression, addiction, OCD, and schizophrenia.
  • Analysis of surgical techniques relevant to gene therapy delivery.

Main Results:

  • Gene therapy is a growing field in clinical neurosurgery.
  • Neurosurgical techniques used for deep brain stimulation are applicable to gene therapy delivery.
  • Several psychiatric disorders show potential for gene therapy interventions.

Conclusions:

  • Gene therapy holds significant potential for treating psychiatric disorders.
  • Neurosurgeons are expected to play a key role in advancing psychiatric gene therapy.
  • Further research is needed to address unique challenges in psychiatric gene therapy.