Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary nonfunction. Is there a contribution from the back table bath?

E M Kennedy1, R P Wood, B W Shaw

  • 1Department of Surgery, University of Nebraska Medical Center, Omaha 68198-3280.

Transplantation
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of comorbidities and treatment burden on general well-being among women's cancer survivors.

Journal of patient-reported outcomes·2021
Same author

Survey of public attitudes towards imminent death donation in the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2020
Same author

A vaccine based on recombinant modified Vaccinia Ankara containing the nucleoprotein from Lassa virus protects against disease progression in a guinea pig model.

Vaccine·2019
Same author

Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.

Scientific reports·2018
Same author

Corrigendum to "Quantitative assessment of lung and bladder cancer risk and oral exposure to inorganic arsenic: Meta-regression analyses of epidemiological data" Environmental International 106 :178-206.

Environment international·2017
Same author

Weight-of-evidence evaluation of associations between particulate matter exposure and biomarkers of lung cancer.

Regulatory toxicology and pharmacology : RTP·2016
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
Same journal

Desensitization With Tocilizumab and IVIg: A Prospective Controlled Cohort Study in a Predominantly Black American Population.

Transplantation·2026
See all related articles

Optimizing donor liver preparation temperature significantly reduced primary nonfunction (PNF) in liver transplants. Maintaining a warmer back table bath (2-4°C) improved allograft function and eliminated PNF compared to colder baths (-3 to -1°C).

Area of Science:

  • Hepatology and Transplant Surgery
  • Organ Procurement and Preservation

Background:

  • Primary nonfunction (PNF) of the hepatic allograft is a persistent challenge in orthotopic liver transplantation (OLT).
  • The causes of PNF are often unknown, necessitating investigations into procurement and preparation procedures.
  • Donor liver preparation temperature is a modifiable factor that may influence allograft viability.

Purpose of the Study:

  • To investigate the impact of donor liver back table bath temperature on the incidence of primary nonfunction (PNF) in orthotopic liver transplantation (OLT).
  • To evaluate whether modifying the back table preparation temperature influences early post-transplant hepatic allograft function.

Main Methods:

  • Retrospective analysis of 100 consecutive liver transplants, divided into two groups based on back table bath preparation.

Related Experiment Videos

  • Group I: Donor liver prepared in an ice slurry (lactated Ringer's solution and ice slush) at -3°C to -1°C.
  • Group II: Donor liver prepared in PlasmaLyte slush at 2°C to 4°C.

    • Main Results:

    • Group II (warmer bath) demonstrated significantly lower postoperative transaminase levels compared to Group I (colder bath) (P < 0.05).
    • The incidence of PNF was significantly reduced in Group II (0 PNF) compared to Group I (7 PNF) (P < 0.005).
    • Transaminase levels normalized within 2-3 days post-transplantation in both groups, but were lower in the warmer bath group.

    Conclusions:

    • Modifying the back table preparation procedure to a warmer temperature (2-4°C) positively influenced hepatic allograft function and reduced PNF.
    • Transplant centers should monitor and control the temperature of back table baths during allograft storage and preparation.
    • Optimal back table bath temperature is a critical factor influencing postoperative function of transplanted livers.