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Updated: May 15, 2026

Quantification of Proteins Using Peptide Immunoaffinity Enrichment Coupled with Mass Spectrometry
Published on: July 31, 2011
Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry
Michael A Gillette1, Steven A Carr
1Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
Abstract:
Targeted mass spectrometry (MS) is becoming widely used in academia and in pharmaceutical and biotechnology industries for sensitive and quantitative detection of proteins, peptides and post-translational modifications. Here we describe the increasing importance of targeted MS technologies in clinical proteomics and the potential key roles these techniques will have in bridging biomedical discovery and clinical implementation.
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