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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Preclinical models in radiation oncology.
Jenna Kahn1, Philip J Tofilon, Kevin Camphausen
1Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Radiation Oncology (London, England)
|December 29, 2012
Summary
Preclinical models are crucial for advancing cancer radiotherapy. This review details various models, highlighting their role in identifying targets to improve tumor radiosensitization and develop more effective cancer treatments.
Area of Science:
- Radiation oncology
- Cancer research
- Tumor biology
Background:
- Radiotherapy is a primary cancer treatment modality.
- Preclinical models are vital for radiation oncology research.
- Current models include in vitro cell cultures and in vivo xenografts.
Purpose of the Study:
- To review preclinical models used in radiation oncology.
- To discuss the advantages and disadvantages of these models.
- To highlight their role in discovering molecular targets for tumor radiosensitization.
Main Methods:
- Review of in vitro cell culture assays.
- Analysis of in vivo ectopic and orthotopic xenograft models.
- Evaluation of model utility in simulating in situ tumor biology.
Main Results:
- Various preclinical models exist, each with limitations.
- These models have been instrumental in preclinical testing.
- Models aid in identifying targets for tumor radiosensitization.
Conclusions:
- Effective preclinical models are essential for developing improved cancer therapies.
- Advances in models will facilitate clinical application of radiation targets.
- Model utility is judged by its ability to mimic in situ tumor biology.
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