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Related Experiment Video

Updated: May 15, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Antivirals: past, present and future.

Erik De Clercq¹

¹Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Belgium. erik.declercq@rega.kuleuven.be

Biochemical Pharmacology

|December 29, 2012

Summary

This summary is machine-generated.

Vaccines prevent infections from viruses like hepatitis B and influenza, but not HIV or hepatitis C. Antiviral therapies are crucial for managing viral infections where vaccines are unavailable or incomplete.

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Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Vaccination is a key strategy for preventing viral infections.
Not all viral infections are preventable through current vaccination programs.
Antiviral therapies play a critical role in managing viral diseases.

Purpose of the Study:

To outline the scope of viral infections preventable by vaccination.
To highlight the necessity of antiviral therapies for non-vaccine-preventable viral infections.
To discuss the role of antivirals when vaccination is incomplete.

Main Methods:

Review of existing literature on viral vaccine efficacy.
Analysis of viral pathogens for which vaccines are available.
Identification of viral pathogens requiring alternative control measures.

Main Results:

Vaccines are effective against Hepatitis B Virus (HBV), Varicella-Zoster Virus (VZV), Influenza viruses, Yellow Fever Virus, and poliovirus.
Vaccines are not currently available for Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), Herpes Simplex Virus (HSV), Cytomegalovirus (CMV), and most Hemorrhagic Fever Viruses (HFV).
Antiviral therapy is essential for managing infections without vaccines and for augmenting protection where vaccines are insufficient.

Conclusions:

Vaccination is a successful but limited tool in viral infection control.
Antiviral medications are indispensable for a comprehensive approach to managing viral diseases.
Further research and development are needed for vaccines and therapies against currently untreatable viral infections.