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Genetic features of thyroid hormone receptors

Maha Rebaï1, Imen Kallel, Ahmed Rebaï

  • 1Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, PO Box 1177, 3018 Sfax, Tunisia.

Journal of Genetics
|December 29, 2012
PubMed

Insights

Thyroid hormone receptors (TRs) regulate gene expression and are crucial for physiological processes. Genetic variations in TRs are linked to human diseases, including cancer, highlighting their potential as therapeutic targets.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Thyroid hormone receptors (TRs) are nuclear transcription factors regulating gene expression.
  • TRs are vital for numerous physiological functions.
  • TR dysfunction is associated with human diseases and cancers.

Purpose of the Study:

  • To review genetic variations and alterations of TRs.
  • To explore the role of TRs in disease development, particularly cancers.
  • To establish the functional effects of TR mutations and polymorphisms on disease susceptibility.

Main Methods:

  • Literature review of genetic variations and alterations in TRs.
  • Analysis of the functional effects of TR mutations and polymorphisms.
  • Assessment of the association between TRs and cancer risk.

Main Results:

  • Genetic variations and alterations in TRs are documented in scientific literature.
  • The functional impact of certain TR mutations and polymorphisms on disease susceptibility, especially cancer risk, is established.
  • TRs play a significant role in the pathogenesis of various human diseases.

Conclusions:

  • TRs are critical regulators of gene expression with implications in human health and disease.
  • Genetic alterations in TRs contribute to disease development, including malignancies.
  • Further research into TRs is essential for developing novel therapeutic strategies and biomarkers for cancer treatment.

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