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09:51
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
Dendritic cells and multiple sclerosis: disease, tolerance and therapy
Mohammad G Mohammad1, Masoud Hassanpour, Vicky W W Tsai
1The Laboratory of Neuroinflammation, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney 2010, Australia. d.brown@amr.org.au.
International Journal of Molecular Sciences
|December 29, 2012
Summary
Dendritic cells (DCs) are key innate immune cells involved in multiple sclerosis (MS) and its animal model, EAE. Understanding their role in the central nervous system (CNS) may reveal new therapeutic strategies for MS.
Area of Science:
- Neuroimmunology
- Innate Immunity
Background:
- Multiple sclerosis (MS) is a debilitating neurological disease impacting young adults.
- Current MS therapies often target adaptive immunity but also affect innate immune cells.
- Experimental autoimmune encephalomyelitis (EAE) is a primary animal model for MS research.
Purpose of the Study:
- To review the role of dendritic cells (DCs) in regulating anti-CNS autoimmune responses in MS.
- To discuss the involvement of DCs in MS susceptibility and their therapeutic potential.
- To examine the evidence for functional DCs within the normal CNS and their interaction with lymph nodes.
Main Methods:
- Literature review focusing on dendritic cells (DCs) and multiple sclerosis (MS).
- Analysis of existing evidence regarding DC function in the central nervous system (CNS).
- Consideration of the CNS-lymph node axis in autoimmune responses.
Main Results:
- Dendritic cells (DCs) play a crucial role in both innate and adaptive immune responses relevant to MS.
- Evidence suggests DCs are present and functional within the CNS, influencing autoimmune pathology.
- The interaction between CNS DCs and cervical lymph nodes is critical for immune regulation.
Conclusions:
- Dendritic cells (DCs) are pivotal in MS pathogenesis and represent a potential therapeutic target.
- Further research into the CNS-DC-lymph node nexus could lead to novel site-directed therapies for MS.
- Clarifying the presence and function of DCs in the CNS is essential for advancing MS treatment.
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