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Retinal oximetry using ultrahigh-resolution optical coherence tomography.

Yufeng Ye1, Hong Jiang, Meixiao Shen

  • 1Hangzhou First People's Hospital, Hangzhou, China ; Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|December 29, 2012
PubMed
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This study assessed the repeatability of retinal oximetry using slit-lamp ultrahigh-resolution optical coherence tomography (SL-UHR-OCT). While averaged measurements were consistent, further work is needed to reduce variations in retinal oxygen saturation measurements.

Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Medical Imaging

Background:

  • Retinal oximetry is crucial for assessing eye health.
  • Current methods may have limitations in precision.
  • Slit-lamp ultrahigh-resolution optical coherence tomography (SL-UHR-OCT) offers potential for improved retinal imaging.

Purpose of the Study:

  • To evaluate the repeatability of retinal oximetry.
  • To assess the utility of SL-UHR-OCT for measuring retinal oxygen saturation.
  • To quantify variations in measurements obtained via SL-UHR-OCT.

Main Methods:

  • Developed a novel SL-UHR-OCT system.
  • Acquired fringe patterns from major retinal arteries and veins.
  • Analyzed A-scans at 805 nm and 855 nm to calculate optical density ratios (ODRs) and percentage oxygen saturation.
Keywords:
oximetryultrahigh-resolution optical coherence tomography

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  • Conducted measurements on two separate occasions for each participant.
  • Calculated coefficients of repeatability.

    • Main Results:

    • Mean ODRs for retinal arteries were 0.79 ± 0.86 (session 1) and 0.88 ± 0.97 (session 2).
    • Mean ODRs for retinal veins were -0.08 ± 0.69 (session 1) and 0.14 ± 0.77 (session 2), significantly lower than arteries (P < 0.05).
    • Mean oxygen saturation: retinal artery 94% ± 45% (session 1) and 98% ± 51% (session 2); retinal vein 48% ± 36% (session 1) and 60% ± 40% (session 2).
    • Coefficients of repeatability were 1.44 for arteries and 1.81 for veins.

    Conclusions:

    • SL-UHR-OCT oximetry shows potential for retinal oxygen saturation evaluation.
    • Measurements demonstrated variability, indicating a need for further refinement.
    • Averaged measurements across sessions showed good agreement, but individual measurement precision requires improvement.