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NeutroPhase(®) in chronic non-healing wounds.
John Crew1, Randell Varilla, Thomas Allandale Rocas
1Seton Medical Center Daly City, CA 94015.
International Journal of Burns and Trauma
|December 29, 2012
Summary
NeutroPhase®, a hypochlorous acid solution, significantly accelerated healing in chronic non-healing wounds. This solution proved non-toxic and effective with or without negative pressure wound therapy (NPWT).
Area of Science:
- Wound Healing
- Antimicrobial Agents
- Biotechnology
Background:
- Chronic non-healing wounds (e.g., diabetic, venous stasis, pressure ulcers) represent a significant unmet medical need.
- Common pathogens in these wounds include Staphylococcus (MRSA), Pseudomonas, Enterobacter, Stenotrophomonas, and Serratia spp.
- Current treatments like antibiotics and antiseptics have limitations, including resistance development and potential harm to healing.
Purpose of the Study:
- To evaluate the efficacy of NeutroPhase® as an irrigation solution for chronic non-healing wounds.
- To assess NeutroPhase®'s performance with and without negative pressure wound therapy (NPWT).
Main Methods:
- Case studies involving 5 representative patients with chronic non-healing wounds were analyzed.
- NeutroPhase® (0.01% hypochlorous acid in saline, pH 4-5) was used as an irrigation solution.
- Wound healing was assessed with and without the adjunctive use of NPWT.
Main Results:
- Patients demonstrated profound improvement in wound healing.
- Markedly accelerated rates of wound healing were observed.
- NeutroPhase® was found to be non-toxic to living tissues.
Conclusions:
- NeutroPhase® is a promising irrigation solution for accelerating the healing of chronic non-healing wounds.
- Its efficacy is demonstrated both as a standalone treatment and in conjunction with NPWT.
- The non-toxic nature of NeutroPhase® supports its clinical utility in wound care.
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