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Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Role of Hematopoietic Growth Factors

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Related Experiment Video

Updated: May 15, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

Infectious pathogens and hematologic malignancy.

Hossein Sadrzadeh¹, Seyed M Abtahi, Amir T Fathi

¹Center for Leukemia and the Bone Marrow Transplant Unit, Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Discovery Medicine

|January 1, 2013

Summary

This summary is machine-generated.

Infectious pathogens, like Epstein-Barr virus (EBV), are linked to blood cancers such as lymphomas. Further research may reveal more infectious causes for malignancies, enabling new treatments.

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

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Published on: December 8, 2023

Area of Science:

Oncology
Virology
Hematology

Background:

Infectious pathogens are increasingly recognized as contributors to cancer development.
Early virology studies identified genetic alterations in malignancies linked to viral infections.
Malignancy can be promoted by viral infection and subsequent cellular transformation.

Purpose of the Study:

To review hematologic malignancies associated with infectious organisms.
To highlight specific viral links to lymphomas and leukemias.
To explore the potential for novel prevention and treatment strategies based on infectious etiology.

Main Methods:

Literature review of studies linking infectious agents to hematologic malignancies.
Summarization of research on viruses such as Epstein-Barr virus (EBV) and human T cell lymphotropic virus type I (HTLV-I).
Analysis of epidemiological data and case reports associating infections with cancers.

Main Results:

Several lymphomas, including Hodgkin's lymphoma and Burkitt lymphoma, are associated with infectious agents.
Epstein-Barr virus (EBV) is directly linked to some lymphomas.
Adult T-cell leukemia and lymphoma (ATLL) is caused by human T cell lymphotropic virus type I (HTLV-I) in endemic regions.

Conclusions:

Infectious agents play a significant role in the development of certain hematologic malignancies.
Understanding these links can inform the development of targeted therapies.
Future research may uncover additional infectious causes for cancer, opening new avenues for intervention.