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Updated: May 15, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Intraoperative radiation therapy.

Harold James Wallace1, James H Goodwin

  • 1Division of Radiation Oncology, University of Vermont College of Medicine, Burlington, Vermont, USA. James.Wallace@vtmednet.org

Critical Reviews in Eukaryotic Gene Expression
|January 1, 2013
PubMed
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Radiation therapy, used for over a century, offers curative and palliative treatments for solid tumors. Intraoperative radiation therapy (IORT) minimizes normal tissue exposure by delivering radiation during surgery.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Radiation therapy has been a cornerstone of cancer treatment for over 100 years, evolving significantly in its understanding and application.
  • Conventional external beam radiation therapy often involves irradiating healthy tissues surrounding the tumor, potentially limiting treatment efficacy due to tolerance thresholds.
  • Advancements in technology, such as high-energy linear accelerators, have improved radiation delivery but organ tolerances remain a critical factor.

Purpose of the Study:

  • To describe the techniques, radiobiologic principles, and clinical applications of Intraoperative Radiation Therapy (IORT).
  • To highlight IORT as a method to minimize radiation exposure to normal tissues adjacent to the target volume.
  • To discuss the advantages and disadvantages of various IORT delivery modalities.

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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
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Last Updated: May 15, 2026

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Main Methods:

  • Review of existing literature and established practices regarding Intraoperative Radiation Therapy (IORT).
  • Description of different IORT delivery systems and their technical specifications.
  • Discussion of radiobiologic considerations relevant to IORT and its clinical implementation.

Main Results:

  • Intraoperative Radiation Therapy (IORT) offers various delivery modalities, each with unique benefits and drawbacks.
  • IORT aims to deliver high doses of radiation directly to the tumor during surgery, sparing surrounding healthy tissues.
  • The choice of IORT technique depends on the specific cancer type, tumor location, and patient factors.

Conclusions:

  • Intraoperative Radiation Therapy (IORT) presents a valuable approach to enhance cancer treatment by optimizing radiation delivery.
  • Understanding the specific techniques, radiobiology, and clinical uses of IORT is crucial for its effective application.
  • IORT holds potential for improving outcomes in various solid tumors by maximizing target dose while minimizing normal tissue toxicity.