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Updated: May 15, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
The biology of Mycobacterium cord factor and roles in pathogen-host interaction
Chunmei Li1, Qinglin Du, Wanyan Deng
1Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
Abstract:
Mycobacterium cord factor was long held as a virulence factor contributing to the pathogenesis of Mycobacterium tuberculosis. Abundant studies have shed light on its unique chemical structures, metabolism, and receptors on macrophages. The mechanisms underlying cord factor virulence remain elusive. This progress is summarized in this paper, especially the receptors of cord factor, such as Toll-like receptors and Mincle. This might facilitate better use of cord factor as an adjuvant for tuberculosis therapy or selection of drug targets involved in its biosynthesis to combat tuberculosis.
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