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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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New photoactive compounds to probe cholic acid and cholesterol inside mixed micelles
Edurne Nuin1, Miguel Gómez-Mendoza, Inmaculada Andreu
1Instituto Universitario Mixto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València, Avenida de los Naranjos s/n, 46022 Valencia, Spain.
Organic Letters
|January 1, 2013
Abstract:
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to probe the microenvironment experienced inside these entities. The outstanding capability of MM to solubilize Ch has been demonstrated.
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