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Updated: May 15, 2026
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease
Yin J Chen1, Georg Deutsch, Ramadass Satya
1University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States. WoodtreeYJ@gmail.com
Purpose:
To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD).
Methods:
Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis.
Results:
AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain.
Conclusion:
Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.
