Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Septins01:19

Septins

Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipoxin A 4 (LXA 4 ) for diabetic retinopathy (DR).

Indian journal of ophthalmology·2026
Same author

Effect of essential fatty acids (EFAs) and their metabolites on the growth suppressive action of anti-cancer drug doxorubicin on neuro- and glioblastoma cells in vitro.

Prostaglandins & other lipid mediators·2026
Same author

Arachidonic Acid and Lipoxin A4 Protect Pancreatic β-Cells and Improve Hyperglycemia Induced by Bleomycin.

Journal of biochemical and molecular toxicology·2026
Same author

Is Sepsis an Essential Fatty Acids Deficiency State?

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2025
Same author

Why vitamin C and corticosteroids are inadequate and how essential fatty acids (EFAs) can augment recovery from sepsis.

Nutrition (Burbank, Los Angeles County, Calif.)·2025
Same author

Arachidonic Acid Protects Skeletal Muscle Against Hyperglycaemia-Induced Muscle Atrophy by Modulating Myogenesis and Regulating KLF15 Expression in C57Bl/6 Mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025

Related Experiment Video

Updated: May 15, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Is sepsis a pro-resolution deficiency disorder?

Undurti N Das1

  • 1UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA. Undurti@hotmail.com

Medical Hypotheses
|January 1, 2013
PubMed
Summary

Sepsis involves a systemic inflammatory response, potentially leading to septic shock and organ dysfunction. This study proposes sepsis arises from insufficient pro-resolution bioactive lipids essential for managing inflammation and promoting healing.

Area of Science:

  • Immunology
  • Biochemistry
  • Critical Care Medicine

Background:

  • Sepsis is a life-threatening systemic inflammatory response to infection or injury.
  • Septic shock, characterized by hypotension and organ dysfunction, leads to high mortality.
  • Sepsis pathogenesis involves a shift from excessive inflammation to immunosuppression.

Purpose of the Study:

  • To investigate the role of pro-resolution bioactive lipids in sepsis pathogenesis.
  • To explore the potential therapeutic implications of these lipids in sepsis management.

Main Methods:

  • This study is based on a proposed mechanism and does not detail specific experimental methods.
  • It focuses on the biochemical pathways involving bioactive lipids in inflammatory and resolution processes.

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Main Results:

  • The proposed mechanism suggests a deficiency in pro-resolution lipids (lipoxins, resolvins, protectins, maresins, nitrolipids) contributes to sepsis.
  • These lipids normally suppress inflammation, cytokine production, and leukocyte activation, while enhancing resolution and healing.

Conclusions:

  • Failure to produce adequate pro-resolution bioactive lipids may be a key factor in the development and severity of sepsis.
  • Restoring or enhancing these lipid mediators could offer a novel therapeutic strategy for sepsis and septic shock.