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Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

A treatment-resistant default mode subnetwork in major depression.

Baojuan Li¹, Li Liu, Karl J Friston

¹Department of Automatic Control, College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan.

Biological Psychiatry

|January 1, 2013

Summary

Abnormal functional connectivity in the anterior default mode network (DMN) persists in recovered major depressive disorder (MDD) patients, suggesting a potential biomarker for relapse risk.

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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

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Published on: August 11, 2015

Area of Science:

Neuroscience
Psychiatry
Medical Imaging

Background:

The default mode network (DMN) is implicated in major depressive disorder (MDD) pathophysiology.
Antidepressant treatment effects on DMN functional connectivity remain unclear.
High relapse rates in recovered MDD patients suggest persistent neural abnormalities.

Purpose of the Study:

To investigate persistent abnormalities in DMN functional connectivity in recovered MDD subjects.
To determine if antidepressant treatment normalizes DMN connectivity.
To explore the potential of DMN connectivity as a biomarker for MDD relapse.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was used.
24 MDD patients and 29 healthy controls were scanned.
18 MDD patients were rescanned after 12 weeks of antidepressant treatment.
Group independent component analysis identified DMN subnetworks.
Two-sample t tests compared functional connectivity between groups.

Main Results:

Two DMN subnetworks (anterior and posterior) were identified.
Pretreatment MDD subjects showed increased functional connectivity in both subnetworks compared to controls.
Posterior subnetwork connectivity normalized after treatment.
Anterior subnetwork connectivity remained abnormally high in recovered MDD subjects.

Conclusions:

The DMN dissociates into subnetworks with distinct treatment responses.
Persistent abnormal anterior DMN connectivity in recovered MDD may indicate asymptomatic depression.
This persistent abnormality could serve as a biomarker for relapse risk in MDD.