Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rational Dosage Regimen: Maintenance Dose and Loading Dose

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...

Dosage Regimen: Individualization

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Dose Size and Dosing Frequency: Determination Methods

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The art of diagnosing rare skin tumors: Can DL-CNNs enhance dermatologists' diagnostic accuracy?

European journal of cancer (Oxford, England : 1990)·2025

Same author

Identifying melanoma among benign simulators - Is there a role for deep learning convolutional neural networks? (MelSim Study).

European journal of cancer (Oxford, England : 1990)·2025

Same author

Round window measurements for cochlear implantation with UHR-CT: Importance of the Stenvers plane and membrane size.

European annals of otorhinolaryngology, head and neck diseases·2025

Same author

Evaluation of Stapes Image Quality with Ultra-High-Resolution CT in Comparison with Conebeam CT and High-Resolution CT in Cadaveric Heads.

AJNR. American journal of neuroradiology·2025

Same author

Gender differences in vascular aging and in coronary artery disease pathophysiology.

QJM : monthly journal of the Association of Physicians·2023

Same author

Intercarpal arthrodesis: A systematic review.

Hand surgery & rehabilitation·2023

Search research articles

Related Experiment Video

Updated: May 15, 2026

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Published on: August 2, 2024

CT dose optimisation and reduction in osteoarticular disease.

A Gervaise¹, P Teixeira, N Villani

¹Service d'imagerie Guilloz, hôpital central, CHU de Nancy, 29 avenue du Maréchal-de-Lattre-de-Tassigny, Nancy cedex, France. alban.gervaise@hotmail.fr

Diagnostic and Interventional Imaging

|January 1, 2013

Summary

Computed tomography (CT) offers advanced imaging for bone diseases, but radiation dose reduction is key. Techniques like iterative reconstruction can halve the dose while maintaining image quality.

More Related Videos

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Published on: November 28, 2025

Related Experiment Videos

Last Updated: May 15, 2026

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Published on: August 2, 2024

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Published on: November 28, 2025

Area of Science:

Radiology
Medical Imaging
Orthopedics

Background:

Computed tomography (CT) is crucial for diagnosing osteoarticular diseases.
Advancements in CT technology, including dynamic CT and CT bone perfusion, expand its diagnostic capabilities.
Radiation exposure remains a significant concern in CT imaging.

Purpose of the Study:

To present typical radiation doses in osteoarticular CT examinations.
To discuss methods for optimizing and reducing radiation doses in CT.
To explore dose reduction strategies for specific musculoskeletal CT applications.

Main Methods:

Review of typical radiation doses delivered during CT for osteoarticular diseases.
Analysis of behavioral and technical factors influencing radiation dose.
Evaluation of dose optimization techniques, including milliamps, kilovoltage, and iterative reconstruction.
Discussion of specific applications: dynamic CT, CT bone perfusion, and dual-energy CT.

Main Results:

Iterative reconstruction techniques can reduce CT radiation dose by up to 50% without compromising image quality.
Optimized technical parameters (mA, kV) and iterative reconstruction enable low-dose or ultra-low-dose CT acquisitions.
Behavioral factors, such as adherence to examination indications, remain critical for dose reduction.
Specific protocols for dynamic CT, CT bone perfusion, and dual-energy CT can achieve dose optimization.

Conclusions:

Significant radiation dose reduction in osteoarticular CT is achievable through technical advancements like iterative reconstruction.
Combining technical optimizations with appropriate clinical indications is essential for safe and effective CT imaging.
Low-dose CT techniques can achieve radiation levels comparable to standard X-ray examinations while maintaining diagnostic image quality.