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Updated: May 15, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Relation between serum folate status and blood mercury concentrations in pregnant women
Hyesook Kim1, Ki-Nam Kim, Ji-Yun Hwang
1Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
Objective:
To evaluate the relation between maternal serum folate status and blood mercury in pregnant Korean women.
Methods:
The nutritional status of folate and the blood mercury concentration were measured in pregnant Korean women who participated in a multicenter prospective study from 2006 through 2011. We analyzed existing blood mercury data based on serum folate status at two gestational time points (mid and late pregnancy, n = 1105 and 841, respectively).
Results:
Serum folate concentrations in pregnant women were negatively associated with blood mercury concentrations at mid and late pregnancy (P trend = 0.012 and 0.002, respectively). A general linear model developed after adjusting for covariates indicated a significant negative association between the two at mid and late pregnancy.
Conclusion:
We found a negative association between serum folate and blood mercury concentrations in pregnant Korean women.

