Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary Angle Closure Glaucoma due to Massive Subretinal and Suprachoroidal Hemorrhage in Neovascular Age-Related Macular Degeneration: Clinical Case and Literature Review.

Case reports in ophthalmological medicine·2025
Same author

Pellino-1, a therapeutic target for control of SARS-CoV-2 infection and disease severity.

Antiviral research·2024
Same author

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.

Nature communications·2024
Same author

Kayser-Fleischer ring and sunflower cataract in Wilson disease.

QJM : monthly journal of the Association of Physicians·2024
Same author

Requirement of the N-terminal region of nonstructural protein 1 in cis for SARS-CoV-2 defective RNA replication.

Journal of virology·2024
Same author

HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage.

Frontiers in cellular and infection microbiology·2024

Related Experiment Video

Updated: May 15, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Interplay between viruses and host mRNA degradation.

Krishna Narayanan1, Shinji Makino

  • 1Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555-1019, USA. krnaraya@utmb.edu

Biochimica Et Biophysica Acta
|January 1, 2013
PubMed
Summary
This summary is machine-generated.

Viruses manipulate cellular messenger RNA (mRNA) degradation to control gene expression and establish infection. This review details viral strategies for evading or exploiting RNA decay pathways.

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

Related Experiment Videos

Last Updated: May 15, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

Area of Science:

  • Molecular Biology
  • Virology
  • Gene Expression Regulation

Background:

  • Messenger RNA (mRNA) degradation is vital for controlling cellular gene expression.
  • Viruses must interact with host RNA degradation machinery for successful replication.
  • Understanding these interactions is key to deciphering host-pathogen dynamics.

Purpose of the Study:

  • To review viral strategies for manipulating cellular mRNA degradation.
  • To provide insight into regulatory mechanisms of gene expression during viral infections.

Main Methods:

  • Literature review of studies on virus-host RNA interactions.
  • Analysis of viral mechanisms to circumvent or co-opt RNA decay pathways.

Main Results:

  • Viruses employ diverse strategies to disarm RNA decay pathways.
  • Some viruses promote host mRNA degradation for selective viral gene expression.
  • Viral manipulation alters host-pathogen interactions and gene expression dynamics.

Conclusions:

  • Viral interactions with mRNA degradation are complex and multifaceted.
  • These interactions offer insights into regulating gene expression during infection.
  • Targeting these mechanisms could impact viral pathogenesis.