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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

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Related Experiment Video

Updated: May 15, 2026

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

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Published on: September 5, 2013

A Staphylococcus xylosus isolate with a new mecC allotype.

Ewan M Harrison1, Gavin K Paterson, Matthew T G Holden

  • 1University of Cambridge, Department of Veterinary Medicine, Cambridge, United Kingdom.

Antimicrobial Agents and Chemotherapy
|January 1, 2013
PubMed
Summary

A new variant of the mecA gene, mecC1, was discovered in Staphylococcus xylosus. This finding expands our understanding of mecC gene diversity and its presence in different bacterial species.

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Area of Science:

  • Microbiology
  • Genetics
  • Antimicrobial Resistance

Background:

  • The mecA gene confers methicillin resistance in staphylococci.
  • A novel mecA variant, mecC (mecA(LGA251)), has been previously identified in Staphylococcus aureus.
  • Understanding the diversity and distribution of resistance genes is crucial for public health.

Purpose of the Study:

  • To identify and characterize novel variants of the mecC gene.
  • To investigate the genetic context and mobile genetic elements associated with the newly identified mecC allotype.

Main Methods:

  • Whole-genome sequencing of Staphylococcus xylosus isolates.
  • Bioinformatic analysis to identify gene variants and mobile genetic elements.
  • Comparison with known staphylococcal cassette chromosome mec (SCCmec) elements.

Main Results:

  • Identification of a new mecC allotype, designated mecC1, in a Staphylococcus xylosus isolate.
  • The mecC1 gene was found within a class E mec complex (mecI-mecR1-mecC1-blaZ).
  • This complex is located at the orfX locus, resembling a staphylococcal cassette chromosome mec element (SCCmec) remnant, sharing genes with type XI SCCmec.

Conclusions:

  • The discovery of mecC1 in Staphylococcus xylosus highlights the broader genetic diversity of mecC.
  • This finding suggests potential horizontal gene transfer mechanisms for mecC variants.
  • Further research is needed to understand the prevalence and clinical significance of mecC1.