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Nogo-A downregulation improves insulin secretion in mice

Claire B Bonal1, Delphine E Baronnier, Caroline Pot

  • 1Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Diabetes
|January 1, 2013
PubMed
Summary

Inhibiting Nogo-A in pancreatic beta cells enhances insulin secretion and glucose control in type 2 diabetes (T2D) models. This suggests targeting Nogo-A could be a new T2D therapy by boosting vagal nerve stimulation.

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