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Updated: May 15, 2026

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A cold radial maze for long-lasting spatial memory in mice.

Sándor Vizi1, Isabelle M Mansuy

  • 1Brain Research Institute, Medical Faculty, University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Zürich, Switzerland. vizi.sandor@freemail.hu

Journal of Neuroscience Methods
|January 1, 2013
PubMed
Summary

Researchers developed a new cold radial maze test for mice to assess spatial learning and memory. This method reliably establishes long-lasting memory without negative side effects, aiding research into memory disorders.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • Spatial learning and memory are crucial cognitive functions.
  • Existing behavioral tests for rodents can have limitations and side effects.
  • Developing species-specific, behaviorally relevant tests is important for accurate assessment.

Purpose of the Study:

  • To establish a novel spatial learning and memory test for mice.
  • To tailor test conditions to natural mouse behaviors.
  • To create a reproducible and reliable method for assessing spatial memory.

Main Methods:

  • Introduction of the cold radial maze, a dry-land testing apparatus.
  • Utilizing a consistent motivation system tailored to mice.
  • Implementing conditions that limit adverse experiences to the testing duration.

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Last Updated: May 15, 2026

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Main Results:

  • The cold radial maze successfully trained mice, establishing spatial memory.
  • The induced memory was long-lasting, resistant to disruption, and reversible.
  • The test demonstrated reproducibility without significant undesirable side effects.

Conclusions:

  • The cold radial maze is a novel, effective behavioral technique for studying spatial learning and memory in mice.
  • This method offers a reproducible way to assess memory without common adverse effects.
  • The test may be valuable for investigating mouse models of human memory impairment conditions.