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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Histology of the Small Intestine01:27

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Related Experiment Video

Updated: May 15, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Henoch-Schönlein disease localized in the appendix.

S M M de Castro1, P Joosse, C Unlü

  • 1Department of Surgery, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands, stevedecastro@me.com.

Indian Journal of Pediatrics
|January 1, 2013
PubMed
Summary
This summary is machine-generated.

A 16-year-old boy with acute abdomen symptoms was diagnosed with Henoch-Schönlein disease after appendicitis surgery revealed unusual findings. This case highlights the importance of considering systemic vasculitis in abdominal emergencies.

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Last Updated: May 15, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

  • Pediatric Gastroenterology
  • Pediatric Surgery
  • Rheumatology

Background:

  • Acute abdomen in adolescents often suggests appendicitis, necessitating prompt surgical evaluation.
  • Henoch-Schönlein disease (HSP) is a common childhood vasculitis, typically presenting with rash, arthritis, abdominal pain, and kidney disease.
  • Gastrointestinal manifestations of HSP can mimic surgical emergencies, posing diagnostic challenges.

Observation:

  • A 16-year-old male presented with acute abdominal pain, initially suspected as acute appendicitis based on ultrasonography.
  • Intraoperative findings revealed appendiceal and terminal ileum abnormalities suggestive of vasculitis, atypical for simple appendicitis.
  • Postoperative development of purpura and arthralgia confirmed Henoch-Schönlein disease.

Findings:

  • Histopathological examination of the appendix and skin biopsy confirmed leukocytoclastic vasculitis, characteristic of HSP.
  • The appendix displayed a distal end with a red, vasculitis-like appearance.
  • A circular, vasculitis-like red band was noted in the terminal ileum during surgery.

Implications:

  • This case underscores the critical need to consider systemic vasculitis, such as Henoch-Schönlein disease, in the differential diagnosis of acute abdomen in pediatric patients.
  • Early recognition and appropriate management of HSP can prevent complications and guide surgical decision-making.
  • Highlighting the diverse gastrointestinal presentations of HSP is crucial for pediatric surgeons and gastroenterologists.